Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of Parkinson's disease
Identifieur interne : 001124 ( Main/Exploration ); précédent : 001123; suivant : 001125Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of Parkinson's disease
Auteurs : Annalisa Pinna [Italie] ; Silvia Pontis [Italie] ; Franco Borsini [Italie] ; Micaela Morelli [Italie]Source :
- Synapse [ 0887-4476 ] ; 2007-08.
English descriptors
- KwdEn :
Abstract
Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A2A receptor antagonists might represent a promising nondopaminergic therapeutic tool for the treatment of PD. Those studies demonstrated the ability of adenosine A2A receptor antagonists to potentiate l‐dopa‐mediated motor improvement, whereas very little is known about counteraction of specific motor deficits and on the effects of these compounds when administered alone. To this aim we evaluated the effects of different adenosine A2A receptor antagonists on initiation of movement deficits, gait impairment and sensory‐motor deficits, induced in rats by a unilateral 6‐hydroxydopamine lesion of dopaminergic nigrostriatal neurons. The following tests were used: (1) initiation time of stepping; (2) adjusting step (stepping with forelimb was measured as the forelimb was dragged laterally); (3) vibrissae‐elicited forelimb placing (as index of sensory‐motor integration deficits). Acute administration of the A2A receptor antagonists SCH 58261 (5 mg/kg i.p.) and ST 1535 (20 mg/kg i.p.) similarly to l‐dopa (6 mg/kg i.p.) counteracted the impairments in the initiation time of stepping test, in the adjusting step and in the vibrissae‐elicited forelimb placing induced by the lesion. The intensity of the effect was l‐dopa > SCH 58261 > ST 1535. The results provide the first evidence that blockade of A2A receptors is effective in antagonizing specific motor deficit induced by DA neuron degeneration, such as initiation of movement and sensory‐motor integration deficits, even without l‐dopa combined administration. Synapse 61:606–614, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/syn.20410
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of Parkinson's disease</title>
<author><name sortKey="Pinna, Annalisa" sort="Pinna, Annalisa" uniqKey="Pinna A" first="Annalisa" last="Pinna">Annalisa Pinna</name>
</author>
<author><name sortKey="Pontis, Silvia" sort="Pontis, Silvia" uniqKey="Pontis S" first="Silvia" last="Pontis">Silvia Pontis</name>
</author>
<author><name sortKey="Borsini, Franco" sort="Borsini, Franco" uniqKey="Borsini F" first="Franco" last="Borsini">Franco Borsini</name>
</author>
<author><name sortKey="Morelli, Micaela" sort="Morelli, Micaela" uniqKey="Morelli M" first="Micaela" last="Morelli">Micaela Morelli</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D98AFA4613C6BF54FA2BB3FD831C9A18FD90EACE</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/syn.20410</idno>
<idno type="url">https://api.istex.fr/document/D98AFA4613C6BF54FA2BB3FD831C9A18FD90EACE/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002390</idno>
<idno type="wicri:Area/Main/Curation">002065</idno>
<idno type="wicri:Area/Main/Exploration">001124</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of Parkinson's disease</title>
<author><name sortKey="Pinna, Annalisa" sort="Pinna, Annalisa" uniqKey="Pinna A" first="Annalisa" last="Pinna">Annalisa Pinna</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Cagliari, CNR Institute of Neuroscience, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Toxicology and Centre of Excellence for NeuroBiology of Dependence, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pontis, Silvia" sort="Pontis, Silvia" uniqKey="Pontis S" first="Silvia" last="Pontis">Silvia Pontis</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Cagliari, CNR Institute of Neuroscience, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Borsini, Franco" sort="Borsini, Franco" uniqKey="Borsini F" first="Franco" last="Borsini">Franco Borsini</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Sigma‐Tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morelli, Micaela" sort="Morelli, Micaela" uniqKey="Morelli M" first="Micaela" last="Morelli">Micaela Morelli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Cagliari, CNR Institute of Neuroscience, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Toxicology and Centre of Excellence for NeuroBiology of Dependence, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Synapse</title>
<title level="j" type="abbrev">Synapse</title>
<idno type="ISSN">0887-4476</idno>
<idno type="eISSN">1098-2396</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-08">2007-08</date>
<biblScope unit="volume">61</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="606">606</biblScope>
<biblScope unit="page" to="614">614</biblScope>
</imprint>
<idno type="ISSN">0887-4476</idno>
</series>
<idno type="istex">D98AFA4613C6BF54FA2BB3FD831C9A18FD90EACE</idno>
<idno type="DOI">10.1002/syn.20410</idno>
<idno type="ArticleID">SYN20410</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0887-4476</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐dopa</term>
<term>SCH 58261</term>
<term>behavioral test</term>
<term>dopamine</term>
<term>stepping test</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A2A receptor antagonists might represent a promising nondopaminergic therapeutic tool for the treatment of PD. Those studies demonstrated the ability of adenosine A2A receptor antagonists to potentiate l‐dopa‐mediated motor improvement, whereas very little is known about counteraction of specific motor deficits and on the effects of these compounds when administered alone. To this aim we evaluated the effects of different adenosine A2A receptor antagonists on initiation of movement deficits, gait impairment and sensory‐motor deficits, induced in rats by a unilateral 6‐hydroxydopamine lesion of dopaminergic nigrostriatal neurons. The following tests were used: (1) initiation time of stepping; (2) adjusting step (stepping with forelimb was measured as the forelimb was dragged laterally); (3) vibrissae‐elicited forelimb placing (as index of sensory‐motor integration deficits). Acute administration of the A2A receptor antagonists SCH 58261 (5 mg/kg i.p.) and ST 1535 (20 mg/kg i.p.) similarly to l‐dopa (6 mg/kg i.p.) counteracted the impairments in the initiation time of stepping test, in the adjusting step and in the vibrissae‐elicited forelimb placing induced by the lesion. The intensity of the effect was l‐dopa > SCH 58261 > ST 1535. The results provide the first evidence that blockade of A2A receptors is effective in antagonizing specific motor deficit induced by DA neuron degeneration, such as initiation of movement and sensory‐motor integration deficits, even without l‐dopa combined administration. Synapse 61:606–614, 2007. © 2007 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
</region>
<settlement><li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Pinna, Annalisa" sort="Pinna, Annalisa" uniqKey="Pinna A" first="Annalisa" last="Pinna">Annalisa Pinna</name>
</noRegion>
<name sortKey="Borsini, Franco" sort="Borsini, Franco" uniqKey="Borsini F" first="Franco" last="Borsini">Franco Borsini</name>
<name sortKey="Morelli, Micaela" sort="Morelli, Micaela" uniqKey="Morelli M" first="Micaela" last="Morelli">Micaela Morelli</name>
<name sortKey="Morelli, Micaela" sort="Morelli, Micaela" uniqKey="Morelli M" first="Micaela" last="Morelli">Micaela Morelli</name>
<name sortKey="Pinna, Annalisa" sort="Pinna, Annalisa" uniqKey="Pinna A" first="Annalisa" last="Pinna">Annalisa Pinna</name>
<name sortKey="Pontis, Silvia" sort="Pontis, Silvia" uniqKey="Pontis S" first="Silvia" last="Pontis">Silvia Pontis</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001124 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001124 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:D98AFA4613C6BF54FA2BB3FD831C9A18FD90EACE |texte= Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |